Botox vs. Dysport vs. Xeomin: Which Wrinkle Relaxer Is Right for You?

Patients ask me some version of this every single week: “Should I get Botox or Dysport? Is one actually better?” It’s a fair question, and the marketing around these products doesn’t make it any clearer. So let me give you the honest, injector’s-eye answer I give in my chair at Rejuvenate Austin.

Dr. Jessica Wright, board-certified surgeon, founder of Rejuvenate Austin

Is Dysport better than Botox?

Neither is universally “better.” Botox and Dysport are both FDA-approved neuromodulators that relax the muscles creating dynamic wrinkles, and for most patients they deliver very similar results. The practical differences: Dysport tends to kick in a couple days faster and spreads a little more, which can be an advantage for larger areas like the forehead, while Botox is the most-studied option and tends to be more precise for small, targeted areas. But here’s the honest truth: for the majority of patients, the injector matters far more than which of these three you choose.

What Botox, Dysport, and Xeomin have in common

All three are neuromodulators, purified proteins that temporarily block the nerve signal telling a muscle to contract. Relax the muscle, and the dynamic lines that muscle creates (forehead lines, frown lines, crow’s feet) soften with it. All three are FDA-approved and all three are temporary.

One note on timing before you read the table: onset is when you first notice your muscles starting to relax, but all three reach their full effect around 14 days. Don’t judge your result before then; the day-3 look is not the final look.

What they are not: dermal fillers. Neuromodulators relax muscle to smooth movement-related wrinkles; fillers add volume to fill static lines and restore contour. Many of my patients use both. If volume is your goal, that’s a dermal filler conversation, not this one.

At-a-glance comparison

Botox Dysport Xeomin
Active ingredient onabotulinumtoxinA abobotulinumtoxinA incobotulinumtoxinA
FDA approved 2002 2009 2010
Onset of results 5 to 7 days 2 to 3 days 5 to 7 days
Full effect About 14 days About 14 days About 14 days
Spread pattern Tighter, precise Slightly broader Tighter, like Botox
Typical longevity About 3 months About 4 months About 3 months
Often best for Most patients; precise areas Larger areas; faster onset Patients developing resistance to Botox or Dysport

Botox: the benchmark

Botox is the most-studied wrinkle treatment on the market and the single most common thing I do at Rejuvenate Austin. It’s been FDA-approved since 2002, and it’s the name most patients walk in asking for. For a first-time patient, it’s almost always where I start. It’s predictable, precise, and we have two decades of data behind it. I dose conservatively to start, because you can always add; you can’t subtract.

Dysport: faster, broader

Dysport uses a slightly different formulation that tends to take effect faster, often 2 to 3 days versus 5 to 7 for Botox, and spreads a bit more from each injection point. That broader spread is exactly what you want across a large, uniform area like the full forehead, and the faster onset is handy when there’s an event on the calendar. That said, spread is something a skilled injector controls through placement and dosing, which is a big part of why the injector matters more than the brand. Dysport also tends to last a touch longer for many patients, closer to four months. It’s not “stronger” than Botox; it’s dosed differently, which is why you shouldn’t compare the two by unit count.

Xeomin: the “pure” option

Xeomin is sometimes called the “naked” neuromodulator because it’s a purified formulation, without the surrounding proteins the others carry. Here’s where it earns its place in my practice: over time, some longtime patients start developing antibodies to Botox and Dysport, and their results stop lasting the way they used to. When that happens, I move them to Xeomin. Because it’s purified, it helps reduce that antibody response, and I’ll typically keep a patient on Xeomin for one to two years before we reassess. It’s the tool I reach for when a reliable Botox or Dysport result starts fading faster than it should.

So which one should you get?

Here’s the part the brand marketing leaves out: the differences between these three are real but modest, and the skill and eye of your injector will affect your result far more than the label on the vial. Placement, dosing, and an honest read of your facial anatomy are what separate a natural, refreshed result from a frozen or uneven one. That’s also why spread and precision aren’t fixed by the product; a good injector manipulates both.

That’s why I don’t sell you on a brand. At your consultation we talk through your goals, your treatment areas, and your history with injectables, and I recommend the option I’d choose if I were in your seat.

What about cost?

Pricing depends on the number of units your treatment areas need, which is why I don’t quote a flat price online; it wouldn’t be honest. At your visit I’ll tell you exactly how many units I’d recommend and what that costs before we do anything, and we’ll review any current specials. You confirm before we inject.

Frequently asked questions

Is Dysport better than Botox?
Neither is universally better. Both are FDA-approved neuromodulators with similar results for most patients. Dysport acts a bit faster (2 to 3 days vs. 5 to 7) and spreads slightly more, which suits larger areas; Botox is the most-studied option and is often more precise for small areas. The injector matters more than the brand.

How long do Botox, Dysport, and Xeomin last?
For most patients, Botox and Xeomin last about 3 months and Dysport about 4 months, then wear off gradually. Staying consistent tends to keep results smoother over time.

How fast do they work?
Dysport starts showing in about 2 to 3 days, Botox and Xeomin in about 5 to 7. All three reach full effect around 14 days, so give it two weeks before judging the result.

Can you switch between Botox, Dysport, and Xeomin?
Yes. A common example: when a longtime patient starts developing resistance to Botox or Dysport and results fade faster than they used to, we move to Xeomin for a year or two to reduce that antibody response. We decide together at your consultation.

Which is best for first-time patients?
For most first-timers, Dr. Wright recommends Botox. It’s predictable, well-studied, and dosed conservatively to start.

Where can I get Botox, Dysport, or Xeomin in Austin?
At Rejuvenate Austin, 1301 W 5th St #100, with Dr. Jessica Wright. Book online or call to schedule a complimentary consultation.

Not sure which is right for you? That’s exactly what a consultation is for. Book a complimentary consult with Dr. Wright at Rejuvenate Austin. Book online.

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Rejuvenate Austin4.7
Based on 421 reviews
Angelica E.
2 weeks ago
I’ve had two rounds of Sculptra with Janelle, and I’ve had a wonderful experience both times. She is incredibly easy to talk to, and made me feel comfortable and welcome from the moment I walked in. She takes the time to educate you throughout the entire process, explaining everything clearly. I highly recommend Janelle to anyone looking for a knowledgeable, kind, and talented nurse injector! I love my results so far!
Tatiana T.
1 month ago
Dana is absolutely amazing. Her bedside manner, expertise and patience is unequivocally unmatched. I feel so lucky to have found a provider who truly listens to my concerns and has a genuine desire to ensure her patients are satisfied with the results. In addition, the entire staff at Rejuvenate has been nothing short of kind, attentive and compassionate. I highly recommend this medspa.
Danielle M.
1 month ago
Stephanie S.
2 months ago
From scheduling to checking in at the front desk and meeting my injector I believe janelle? Everything was10/10 I felt so comfortable I LOVEEE HER APPROACH and value her opinion. I went in for Botox and told her my concerns. Will definitely come back/recommend and I just found my new favorite med spa!
Shereen F.
2 months ago
I saw their Botox special on social media. That led to yelp and google reviews which are awesome. I was created with kindness and was taken to the treatment room right away. I didn’t have to wait. Dana came in and is an expert. Her education is impressive. We discussed realistic expectations and other options to help with my concerns. Their packages are worth it and not overly expensive. I also connected with Paloma about microneedling. Once I went over their monthly membership, it gets me a facial every month and a set Botox price of $10 per unit. Other perks as well. I’m stoked I found my new care team. Try them, I bet you’ll love them too.
Chrissy R.
2 months ago
Really clean facility, pleasant people. Barely felt the needles
Whitney
2 months ago
Dana is amazing and always keeps me looking fabulous and youthful. Cannot recommend enough.
Mary H.
2 months ago
Always wonderful. Knowledgeable. Professional and friendly. Excellent guidance. Great result. I love Rejuvenate Austin.
Denise L.
3 months ago
During and after completing Ultherapy and microneedling sessions with Paloma, I vowed I would tell everyone about my outstanding, even “pleasurable” experience with her. And then there was Spring Break. That was mid March, and now it’s early May. The vow keeps pricking my mind, and I just realized, this is actually a very good time to follow through with it. I should begin by saying I’ll be 70yo in November, so I’ve not been generating collagen several decades now, and gravity has taken its toll. My lower face was beginning to sag, and my neck was getting the “turkey flap.” The skin along my jawline had loosened, and the marionette lines around my mouth were deepening. I had dimpling in the chin area, and I don’t even have dimples! What to do? I’d filled them before and wasn’t thrilled. Filler is a tricky thing with me; maybe because I’m thin skinned or simply because I’m older? I’m vain and wasn’t liking the way I looked, but what to do when you don’t have the pocketbook for a face lift, or even just a lower face and neck lift? After consulting with our cherished Dr. Wright, it was decided I’d best be able to reach my goals with separate sessions of both Ultherapy and Microneedling. She paired me with Paloma, and wow, how could an Ultherapy session ever be described as “pleasurable?” Paloma is one of the most engaging, amusing, compassionate, and PROFESSIONAL souls ever. She’s also VERY SKILLED and VERY FOCUSED. How is she so attentive, fun and kind while remaining so intense, concentrating on her work at hand? Throughout the session, I wondered how we could chat so easily as she simultaneously passed the wand that delivered energy waves into to the deeper levels of skin, and calmly reassuring me all the while? She carefully navigated the whole of my face and neck, section by section, always attentive to what the screen was cuing, while keeping me distracted from the “pings.” I’d had this procedure once before with Dr. Jessica, perhaps a decade ago, but I didn’t recall it being this intense. I guess ten years changes things, or maybe the way I experience them? Paloma deliberately told me ahead of time which areas would be more sensitive, and she’d talk me through them with her soft voice and engaging conversation. She used words to encourage me: “One more quick one here,” or “next I’ll be working here, and it will be easier for you.” We spoke about the areas that especially bothered me, and she passed the wand delivering heat energy, and focusing more on those concerns. I don’t have enough knowledge about Ultherapy to speak too confidently, but Paloma may have said the wand signaled where to direct more heat, and she did so either by making another pass or by increasing the intensity of the energy waves? What I DO know is that it’s 2 months later, and I’m FEELING and VISIBLY SEEING the results! I know if I return someday, I’ll be seeing Paloma! Needless to say, I am very pleased, grateful, and happy with the results! Thank you so much, Paloma, and thank you, Dr. Jessica!
EatDrinkDo A.
3 months ago
I love this medspa and the staff. I highly recommend them. They offer everything from lasers and tox to GLP-1, microneedling, and more.
Heather M.
3 months ago
I’ve been going to Rejuvenate Austin for several years. I like the ease of booking appointments and that they have Saturday appointments available. I like the natural looking results and the honest conversation about what to expect as far as results and pricing.
Samantha J.
3 months ago
Just had microneedling with PDRN done last week with Paloma and it was such a great experience. She detailed everything she was doing, asked if I had questions multiple times, made sure I was always comfortable and overall communicated exceptionally! Highly recommend her.
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